Alaska pollock protein as a functional dietary source for promoting skeletal muscle …

Loading metrics Open Access Peer-reviewed Research Article Ayumu Kojima, Risa Mukai, Mizuki Morisasa, Wakako Tawara, Shunsuke Amagaya, Kenjiro Furusho, Norika Tsutsumi, Yukina Tadokoro, Haruto Otsuka, Miu Fujii, Taro Kishida, Atsushi Kuno, Azusa Tomioka, Shinji Okada, Tsukasa Mori,  [ … ], Naoko Goto-Inoue [ view all ] [ view less ] Alaska pollock protein as a functional dietary source for promoting skeletal muscle hypertrophy and lipid metabolic remodeling Ayumu Kojima,  Risa Mukai,  Mizuki Morisasa,  Wakako Tawara,  Shunsuke Amagaya,  Kenjiro Furusho,  Norika Tsutsumi,  Yukina Tadokoro,  Haruto Otsuka,  Miu Fujii x Published: May 13, 2026 https://doi.org/10.1371/journal.pone.0348366 Figures Abstract Alaska pollock protein (APP) promotes skeletal muscle hypertrophy, particularly in fast-twitch fibers. Using a time-controlled feeding model, plasma collected 90 min after APP intake markedly enhanced C2C12 myotube hypertrophy and contractility. At this time point, plasma glucagon-like peptide-1 levels were significantly elevated, suggesting the involvement of circulating factors associated with APP intake. Proteomic and lipidomic analyses of skeletal muscle identified 2302 proteins and 538 lipids, and revealed pronounced remodeling of lipid metabolism, including a 127% increase in docosahexaenoic acid (DHA)-containing phospholipids in hypertrophied fast-twitch fibers, partially resembling endurance training adaptations. APP also upregulated adipose triglyceride lipase and hormone-sensitive lipase in the skeletal muscle, indicating enhanced lipid
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