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In 2017 and 2020, Zejula snagged broad FDA labels for ovarian cancer patients who responded well to a chemotherapy. But in prostate cancer, the PARP inhibitor appears to work only for a niche population—and that's bad news for the drug in its ongoing fight for market supremacy against AstraZeneca and Merck & Co.’s rival Lynparza. In a late-stage clinical trial in patients with newly diagnosed metastatic, castration-resistant prostate cancer (mCRPC), the addition of Zejula to J&J’s Zytiga and prednisone slashed the risk of disease progression or death by 27% in patients with mutations in their homologous recombination repair (HRR) genes. The phase 3 data were unveiled at the American Society of Clinical Oncology Genitourinary Cancers (ASCO GU) symposium. But in patients without HRR abnormalities, Zejula didn’t show any efficacy benefit but instead added toxicity to the Zytiga-prednisone regimen. That part of the readout came in stark contrast to Lynparza’s win at ASCO GU in all patients in the same disease setting regardless of HRR status. By grouping patients into different cohorts by HRR status, J&J intentionally designed the phase 3 MAGNITUDE trial to examine which patients really benefit from the new Zejula combination, Mark Wildgust, Ph.D., vice president of global…

On February 4, 2022, Governor Tim Walz signed House File (H.F.) 1203 into law, which extends the presumption that certain frontline healthcare workers contracted COVID-19 at work if they test positive. The prior presumption had expired on December 31, 2021. This extension applies to COVID-19 illnesses from February 4, 2022, through January 13, 2023. H.F. 1203 is not retroactive, so it does not grant a presumption to those who contracted COVID-19 between January 1, 2022, and February 3, 2022—the day before the effective date of the new law. What is the presumption? In 2020, Minnesota (among several other states) enacted legislation (Minn. Stat. § 176.011, subd. 15 (f)) that created a rebuttable presumption that employees working in certain health and public-safety fields contracted COVID-19 at work if they tested positive for the disease. H.F. 1203 reaffirms that presumption, allowing those employees to obtain workers’ compensation benefits for their illnesses unless their employers can rebut the presumption that they contracted the virus at work. The law applies to licensed peace officers under Stat. § 626.84, subd. 1; firefighters; paramedics; nurses or health care workers, correctional officers, or security counselors employed by the state or a political subdivision at corrections, detention, or…

 People wait to cast their vote at a polling booth, during the second phase of Uttar Pradesh Assembly elections, in Moradabad, Monday, Feb. 14, 2022. (PTI) Lucknow: In the second phase of the ongoing Assembly elections in Uttar Pradesh, a voter turnout of 23.03 per cent was reported till 11 am on Monday, according to the Election Commission of India. Moradabad witnessed the highest percentage of voter turnout of 25.84 per cent followed by Saharanpur (25.16 per cent) and Bijnor (24.51 per cent). Amroha reported a voter turnout of 22.99 per cent till 11 am, while, Sambhal reported 22.91 per cent voter turnout. Budaun reported 21.95 per cent voter turnout while Rampur reported 21.58 per cent voter turnout. Shahjahanpur recorded 21.55 per cent voter turnout and Bareilly reported 20.68 per cent voter turnout. Voting for the second phase of the Uttar Pradesh Assembly elections began on Monday at 7:00 am. The second phase of polling for the state assembly is scheduled for February 14. Altogether 55 assembly constituencies will go to the polls in the second phase covering nine districts of Saharanpur, Bijnor, Amroha, Sambhal, Moradabad, Rampur, Bareilly, Budaun and Shahjahanpur. ...

www.firehouse.com is using a security service for protection against online attacks. This process is automatic. You will be redirected once the validation is complete. Reference ID IP Address Date and Time bbc3a3aa1f090635b64d0001c151d63e 75.98.162.75 02/14/2022 07:37 PM UTC

Kottayam: The family of a 28-years-old youth from Kerala, who was working as an assistant cook on a ship and went missing in the Atlantic ocean, sought help from the Ministry of External Affairs to find him. The youth identified as Justine Kuruvila started his journey from South Africa (Durban) to America on January 31. Speaking to ANI, Shigha, the lost youth's sister said, "The ship started from Durban on January 31. He used to call us every day, but the last call was a week ago. After that day, he stopped answering our calls." "He came back home last November and worked about 6 years in the ship. On February 8, he called my mother. After this, there is no information about Justin. The shipping authority informed us that he was missing from the Atlantic Ocean," his sister added. His brother, Stephen who is also a sailor also stated that they all are praying for Justin and requesting the shipping authorities to find him at the earliest. Manjeesh, a member of Kurichy Panchayath also said they all are searching for him and decided to seek help from the Minister of State, Muraleedharan. "We all are searching for Justin but…

 Bajrang Dal burn an effigy symbolizing Valentine's Day during a protest in Hyderabad, India, Saturday, Feb.12, 2022. (AP Image) Hyderabad: Bajrang Dal members staged protests against Valentine's Day in Hyderabad and requested the government to declare February 14 as Amar Jawan Diwas. Bajrang Dal members burnt greeting cards and effigies of Valentine at Abids Circle in Hyderabad on Saturday. "Valentine's day celebrations are being imposed in the country. The multinational companies in the name of greeting cards and private album songs are earning a lot of money. The Bajrang Dal wants to give the message that in India there are many love stories like Ramayana and Mahabharata," said Kailash, a member of the Bajrang Dal. "More than 40 soldiers sacrificed lives in Pulwama, so the youth needs to understand and take these soldiers as the inspiration, not Valentine's Day. We request the Centre and Telangana government to declare February 14 as Amar Jawan Diwas," he added. ...

“ The research study released a report on the global Online Higher Education market in order to give important market facts such as market stability, growth rate, and financial changes. This research shows economic gains and losses in tabular and bar diagrams and other representative formats so that the future and position of the Online Higher Education market are better understood both domestically and globally. The report also examines the latest market trends, opportunities and challenges, threats, and major strategic activities of firms in the world’s top industries. The global Online Higher Education market Report analyses various main manufacturers of the market by region. The world-class research has been produced with every market-related element with production and supply chain in mind, making it the most appropriate illustration of the main market qualities. Request for a sample report here https://www.orbisresearch.com/contacts/request-sample/5635876 Online Higher Education Key Players In Online Higher Education Report: Khan Academy Linkedin learning Udacity Edx Skillshare Lynda Coursera Udemy Market Arrangement By Online Higher Education Types: Degree Non-degree courses Market Arrangement By Online Higher Education Application: Commerce and management STEM Arts Others The thorough study offers a detailed microscopic examination of the Online Higher Education market. The market research study…

Digital marketing makes advertising your business more accessible than ever. But that doesn’t mean it’s easy, especially if you’re diving into online advertising for the first time.Along with where to advertise, you have to put a ton of thought into who your primary audience is and what ad types you want to use. You’ll also have to consider analytic capabilities, targeting strategies and — of course — the dreaded budget. It’s time to dust off your spreadsheets and get ready to look over every number. Bottom line: There are a lot of intricacies to take into account when you’re picking the best place for your next ad. Here’s a quick overview of what LinkedIn, Facebook, and Google offer.1. LinkedInAdvertising on LinkedIn is a no-brainer. It’s where professionals go to link up, boost their skills and find new opportunities. That means anyone who sees your ads is already thinking in terms of bettering themselves. They’re in the right frame of mind to look at your ad and imagine how you can make their work lives more manageable. Putting an ad on LinkedIn takes some steps off of your plate. Even better, LinkedIn can target ads based on first-party and self-reported information.…

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Microsoft is bringing LinkedIn to Teams. The company today announced that it is bringing the LinkedIn integration to Microsoft Teams soon. Once rolled out Microsoft Teams users will be able to see their colleague’s profiles within one-to-one chats. Also Read - Microsoft testing new Surface Laptop powered by Qualcomm Snapdragon 8cx Gen 3 Microsoft said that with this integration, users can get to know more about their co-workers through the course of their on-boarding or even while working on a special project. It will also help provide significant background information, work history, and links to blog posts from LinkedIn on Teams. Also Read - Microsoft aims to bring Call of Duty and other Activision Blizzard games to Nintendo Switch As far as the availability is concerned, Microsoft said that it will start rolling out LinkedIn integration in Teams starting March 2022, which is when it will be available to all global users across Microsoft Teams web and desktop versions. Also Read - 16-yr-old kid earns lakhs of rupees by just selling PlayStation 5, Xbox consoles How to use LinkedIn in Microsoft Teams Step 1: In Teams, go to the one-on-one chat of the person whose LinkedIn profile you want to check.…